Office space in SoHo is at a premium. SoHo is one of the most popular neighborhoods on the planet to rent office space. Short for South of Houston Street, the upscale neighborhood exudes style, luxury, art, and New York City culture. SoHo enjoys a rich and varied history. It began as a manufacturing area transitioned to a hub for artists and then evolved into one of the most expensive and in-demand locations to live, play, work, shop, and eat in Manhattan.