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The Dark Fields, starring Bradley Cooper, is currently filming on E16th Street, just off Union Square. They will also be in midtown later today, on 6th Avenue and Central Park South.
The movie, based on Alan Glynn's 2002 novel, is about a loser (LaBeouf) who gets his hands on a top-secret pharmaceutical smart pill but soon discovers that it has lethal and lasting side effects. The project is said to be in the vein of Fight Club and The Game.